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In addition, it reverses intracellular acidosis (such as that in renal tubule acidosis), apparently by competing with diphosphopyridine nucleotide as a hydrogen receptor

TB-500 provides complementary anti-inflammatory activity through multiple mechanisms including direct inhibition of NF-B signaling, modulation of immune cell phenotypes, and promotion of inflammatory resolution

World J Gastroenterol 23:4658488 Farges M, Balcerzak D, Fisher B, Attaix D, Bchet D, Ferrara M, Baracos V (2002) Increased muscle proteolysis after local trauma mainly reflects macrophage-associated lysosomal proteolysis

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